By Steven Lipkin, MD, PhD with Jon L. Luoma: In the next decade, we are likely to see a new generation of preimplantation genetic diagnosis, which could lead to the possibility of actually repairing genes in ART [advanced reproductive technologies] embryos affected by genetic disorders. Recent powerful basic science advances using a technique called CRISPR (pronounced “crisper,” and the acronym for the tongue twister “clustered regularly interspaced short palindromic repeats”) have offered robust evidence that it’s possible to repair gene defects in embryos of several mammalian model organisms, including nonhuman primates. This is an inexpensive, remarkably effective gene-editing technique easy enough to be performed in literally thousands of laboratories around the world.
A Q&A with Steven Lipkin, MD, PhD and Jon L. Luoma | We are living in an age that promises to be a watershed in the history of health and medicine. Genetic testing is experiencing the kind of exponential growth once seen with the birth of the Internet as the plummeting cost of DNA sequencing makes it increasingly accessible for individuals and families. In The Age of Genomes: Tales from the Front Lines of Genetic Medicine, which went on sale this week, geneticist Steven Lipkin, MD, PhD and science journalist Jon Luoma explore the transformative potential and risks of genetic technology through the true stories of patients facing devastating neurological diseases, cancer, and other maladies